What comes out of your research depends in large part on what goes into your research models. Responses were compared with those in mice deficient in the cold/menthol receptor, TRPM8, expressed in trigeminal sensory neurons innervating the oral cavity. Inflammation clears from C57BL/6 mice 4-5 weeks post infection (pi), but persists for several months in BALB/c mice. Impaired gastrointestinal health is thought to play a causative role in chronic systemic inflammation leading to disease. A lethal challenge model was developed and the LD(50) was determined to be 1.5 x 10(7)N. caninum tachyzoites/mouse, delivered intraperitoneally. Mice. A standard timed-pregnancy protocol was followed in which 15 female C57BL/6 mice were bred to male C57BL/6 mice. Il10 Knockout mice are useful for studying colitis and immunoregulatory pathways. C57BL/6 mice have a dark brown, nearly black coat. Additional Donor Information: Need something more unique? In this study, C57BL/6 mice were evaluated as a model for Neospora vaccine studies. Description About the C57BL/6 Mouse. Electronic address: Lee.Meakin@bristol.ac.uk. Pirfenidone is an FDA-approved anti-fibrotic drug for systemic use in the treatment of idiopathic lung fibrosis and other fibrotic disorders. Serum … Western blot analyses on P21 revealed significant reductions of synaptophysin and postsynaptic density protein 95 … Mice were allocated into three groups (control, single smoke exposure/day and double smoke … All mice were used at 8–10 weeks of age, and all procedures were approved by the Animal Investigation Committee, Wayne State University. C57BL/6 mice received double target (60 μl) doses of oral CCl 4 for 16 and 32 weeks. Exercise does not enhance aged bone's impaired response to artificial loading in C57Bl/6 mice. For this reason, we evaluated prophylactic treatment of deep partial-thickness burns with pirfenidone in C57BL/6 mice. Add to cart Derived from brain tissues of SPF strain C57BL/6 mice and have been transfected with a lentiviral construct encoding a GFP expression motif. Size: 05-10M cells/vial: Price: $ 150.00: In Stock: 78: Need More? BT was defined as bacterial growth in MLN culture. C57BL/6 is the most often used laboratory mouse strain. Both wild-type and D 2 R deficient mice learn operant behaviors equally well. For mice receiving pAAV/HBV1.2, splenocytes from BALB/c mice expressed significantly higher levels of IFNγ mRNA than those from C57BL/6 mice. Then, effects of menthol on oral nicotine aversion were determined. 1. Ninety adult female C57BL/6 mice (Lebanese American University animal breeding program), aged 8–10 weeks, were used in this study. Figure Figure1 1 depicts the latency for both genotypes to ambulate to a dish to retrieve an unhidden food pellet. Of the 15 females that were bred, 7 became pregnant (47% preg-nancy rate). Experimental Animals. The C57BL/6 mouse is the most commonly-used inbred mouse strain available and is employed in numerous research areas, including immunology, genetics, diabetes and obesity, neurobiology, cardiovascular biology, and developmental biology. C57BL/6 male mice were randomly assigned to three diets for 7 weeks: low fat (LF, 16% kcal from fat), HF (HF, 60% kcal from fat), or HF with 5% ginger powder in diet (HF + G). 2.2. The distribution and activation state of intrahepatic, circulating and MLN mononuclear cells were determined by flow-cytometry. The C57BL/6 mouse is the most commonly used inbred mouse strain and the first inbred mouse strain whose genome was fully sequenced. Avaliable in histological tissue section on glass slide (HS) or paraffin-embedded tissue block (PETB) formats. Price from $ 9.99 to $ 1999.99. c57bl 6 mice - by Bioz Stars, 2021-01 98 / 100 stars Related Products / Commonly Used Together. Price: Qty: Please enter an integer. (2)School of Clinical Sciences, University of Bristol, Bristol BS2 8DZ, UK. Tissues are from healthy animals, unless otherwise indicated. However, there was a two-fold lower level of DNA synthesis in C57BL/6 mice relative to C3H mice after partial hepatactomy, though partial hepatectomy is a tumour promoter in C57BL/6 but not in C3H mice (Bennett et al, 1995). Animals were kept in groups of five per cage under 12 h light/12 h dark cycle conditions and at a constant temperature (22 ± 2 °C) at LAU animal facility. Mice were fed by standard mouse food and water and stayed in an environment with a 12-hour light/dark No mouse with cirrhosis developed ascites or BT. Although these novel T cell epitopes will be useful in future studies of C57BL/6 mice, they will also be important for the study of T cells in the CB6F1 model, a cross between C57BL/6 and BALB/c mice, which is also frequently used as a murine model for RSV infection (27, 34–40). Download Certificate Of Analysis Details . All mice used in this study were of the C57BL6 strain ob-tained from the Charles River Laboratories (Wilmington, MA). Drug-loaded liposomes were injected intravenously to deplete macrophages from C57BL/6 mice, and effective removal of CD11b+ cells from the spleens and stomachs of mice was confirmed by immunofluorescence microscopy. Experiment design. Meakin LB(1), Udeh C(2), Galea GL(3), Lanyon LE(3), Price JS(3). They are routinely used as the background strain for generation of congenics carrying modified genes and/or transgenes. Male 7-week-old C57BL/6 mice (n = 40) purchased from Nanjing University Model Animal Research Institute (Nanjing, China) were housed in plastic cages in a room with controlled temperature (22°C ± 1°C) and humidity (55 ± 15%). Fig. 1996 Aug 15;98(4):1010-20). Mutant Mice - C57BL/6/BrdCrHsd-Tyrc - 103. Male C57BL/6 mice (6-week-old, 18-20g) purchased from Shanghai SLAC Laboratory Animal Center Inc. (Shanghai, China) were treated after acclimatizing to laboratory conditions for 1 week. Sensitive to teratogenic effects of acetazolamide (2/6) (Green et al., 1973., 1973). Mice were maintained on a regular pellet diet with access to fresh water. Price from $ 9.99 to $ 1999.99. female c57bl 6 mice - by Bioz Stars, 2021-01 92 / 100 stars Related Products / Commonly Used Together. Dorsal hair in the telogen phase of 8-week-old C57BL/6 mice was depilated to synchronize anagen induction. Read 3 answers by scientists to the question asked by Linn Amanda Syding on Sep 5, 2018 Transient elimination of macrophages from C57BL/6 mice during the early period of infection reduced the gastric pathology induced by H. pylori SS1 but did not affect the … Author information: (1)School of Veterinary Sciences, University of Bristol, Bristol BS40 5DU, UK. MATERIALS AND METHODS Mice. 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