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Nov 12, 2018 | Individually Ventilated Caging, Rodent Housing, by Rainey Hufstetler, HERA | Laboratory Equipment | 11/07/2018. Lab Rat Chat talks to AAALAC's Dr. Diggs. The fumigation programme was started with methyl bromide treatment directed primarily against arthropods, followed by ammonia spray to kill coccidial oocysts and concluded by three formaldehyde treatments with fog and spray against … Large Animal Bio Safety Level 3 Agriculture Complex (BSL3 AG) Public Health BSL 3 Facilities. Drinking water must be treated as a consumable and be sterilized. 0000004735 00000 n
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These facilities, sometimes referred to as specific pathogen-free (SPF) facilities, may be designed as stand-alone buildings used for production facilities or as components of larger animal research programs. Biocytogen’s AAALAC accredited SPF animal facilities provide optimal breeding environments. Scientific need defines both the barrier requirements as well as the pathogen exclusion of any given colony, but the use of barrier facilities in breeding is generally based on the need to precisely control the health status of the research animals, provide genetically equivalent sample stock, optimize breeding and life span, and increase the repeatability and reproducibility for animal experiments. Integral epoxy floor, wall, and ceiling coatings are recommended though monolithic, slip resistant surfaces. The initial sanitization and sterilization of a newly built animal facility for the breeding and holding of specified pathogen free (SPF) rats and mice is described. endstream
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Our experts design the most efficient breeding scheme to save on … 0000003830 00000 n
Animal Selection and Preoperative Preparation. (4) Animal infection experiment in biosafety laboratory. She is Director of Animal Facilities at the Garvan Institute of Medical Research inSydney, Australia and is CEO of the Australian BioResources facility. SPF animals are special stock of animals that are kept in specific pathogen free facilities under rigorous monitoring system, which are subjected to sensitive and accurate diagnostic methods. Each facility has its own waste profile. In this episode, Lab Rat Chat hosts talk to AAALAC Senior Director Dr. Helen Diggs about AAALAC's mission and work, and why AAALAC has been "so critical to the continued evolution of animal care and use standards." 0000070700 00000 n
Reduction: use of methods that enable researchers to obtain comparable levels of information from fewer animals, or to obtain 97 0 obj
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As such, animal holding rooms, as well as fumigation entry points to the suite, shall be designed for worst-case scenario caging or isolator size requirements and should include turn-radii and doors sized to accommodate larger caging. The LAR staff will implement and monitor compliance with SPF standards of care and use of all SPF-designated mice. p. 16 3. Animal Pi ki NPicking N C Research Facilities 2009 Tradeline Conference Series BARRIER FACILITIES N CtNew Cost-Eff ti S l ti f Effective Solutions from a Range of Options Concurrent Forum Session Concurrent Forum Session J“J” October 19, 2009 Lloyd E.L. Fisk, AIA LEED AP Reseaesea c ac es es grch Facilities Design She has written and presented to a variety of audiences including I2SL, CDC and ABSA on sustainable approaches in containment facility design. 0000006466 00000 n
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The Laws, Regulations, and Guidelines for Animal Research in China Mainland (China), Japan, and South Korea (Korea) will be discussed in this chapter. x�b```c``��E� cc`a�X��$��3`� �u��K' In design terms, circulation in an animal facility refers to the movement of animals, materials, and personnel into, out of and within the facility, and between spaces in the facility. 0000047554 00000 n
Consider Physical and Operational Requirements Dr Jenny Kingham is a veterinarian, with 25 years experience in the management and design of laboratory animal facilities. The puppies are housed at the back. Not only does this type of separation lessen the strain on the mechanical system, but it also lessens the transmission probability between one side of the wall and the other via improperly sealed penetrations that permit possibly contaminated air, water or vermin from adjacent spaces to infiltrate the barrier facility. Specific-pathogen free (SPF) animals were introduced into biomedical research in the early 1960s to reduce the incidence of disease into experimental design. The Department of Laboratory Animal Resources (LAR) maintains a specific pathogen free (SPF) animal area for SPF mice. The housing recommended will meet most animals’ needs for up to about a two-week shelter … Animal transport Facility barriers SPF solutions Multimodal transport Animal care Anesthesia (injection/gas) The staff includes 5 full-time employees plus student labor. laboratory animal facilities — characteristics, design and development, 2003. of air. Barrier suites should be located within a clearly demarcated, access-controlled area inside the building. As scientific rigor continues to evolve, it has become increasingly important to document any external factors that might have an impact on the final research data. The walls and ceilings within a barrier facility must withstand the pressure differentials within the suite, as well as prevent vermin transmission. 0000059926 00000 n
Universal design is a planning approach which focuses on the diversity of building users during the facility design process. 0000100748 00000 n
Each country recognizes modern society's ethical concerns over the use of animals in research and each has developed their own regulatory framework to support the humane care and use of laboratory animals. Change sequences should be incorporated at the suite entry to permit personnel to change into complete SPF-dedicated personal protective equipment (PPE) including sterilized footwear, scrubs or gowning, eyewear, and any additional safety covering necessary for working with animals. This includes, and truly begins, with proving that animal models forming the basis of research are as homogenous as feasible from the outset, and this has driven demand for rigorous design of SPF barrier facilities. 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