ob/ob Mice (JAX™ Mice Strain) Details. These Mighty Mice have twice the muscle mass of normal mice that possess the gene for producing myostatin. 5 0 obj x�%�A�@�}O�(��'.�r�^���� Resistance is expressed by macrophages and other cells in vitro (J:6649, J:5940) but could not be transferred to susceptible animals by transfer of macrophages from resistant mice (J:6149). C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss. PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. 2020-02-06T13:32:01+05:30 C57BL/6J was the DNA source for the international collaboration that generated the first high quality draft sequence of the mouse genome. Macronutrient diet selection in thirteen mouse strains. There are no related strains using this filter. The A variant of this SNP has also been identified in strain LG/J. <>>>/BBox[0 0 585 783]/Length 114>>stream Skip to main content. BALB/c is an albino, laboratory-bred strain of the house mouse from which a number of common substrains are derived. BMC Neurosci 2:11. Exp Anim 58(2):141-9, Miller MW; Duhl DM; Vrieling H; Cordes SP; Ollmann MM; Winkes BM; Barsh GS. Volume Pricing Program
19 0 obj x�+� � | Sequence analysis shows that relative to the a variant of C3H/HeJ the b variant has point mutations that result in isoleucine instead of valine at amino acid 9, glutamine instead of leucine at amino acid 52, and phenylalanine instead of isoleucine at amino acid 71, all within the amino terminal scavenger receptor cysteine-rich D1 domain, in addition to 7 silent point mutations. 27 0 obj 7 0 obj Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. They are the most widely used and best-selling mouse strain, due to the availability of congenic strains, easy breeding, and robustness. 1�^���|7�PE$HG�cD�d�ҥ8C&���GӦmйM���u
A{l��0�^aU[���"��֔���~%��6>��m endobj x�+� � | Genes Dev 8(4):481-90, Bultman SJ; Michaud EJ; Woychik RP. To NIH in 1951 from The Jackson Laboratory at F32. endstream Am J Physiol Regul Integr Comp Physiol 278(4):R797-805, Smith RS; Roderick TH; Sundberg JP. Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice. This deletion results in the absence of the NNT protein, and is associated with impaired glucose homeostasis control and reduced insulin secretion. xmp.iid:c31c0f8a-1532-ed4d-a998-9ccad6f57fa8 The conditional Stat3 knockout mice (B6.129S1-Stat3tm1Xyfu /J), Rosa26-LSL-tdTomato (B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze /J), and Rosa26-LSL-DTA (Gt(ROSA)26Sortm1(DTA)Lky /J) were obtained from The Jackson Laboratory (Bar Harbour, ME). Genetics of age-related hearing loss in mice. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. The resistance allele at the Mx1 locus, under induction by alpha/beta interferon, produces the 75 kDa protein MX-1, which confers resistance to the influenza virus, in the nuclei of cells carrying the allele. Strains 6 and 10 separated about 1937. J Lipid Res 31(5):859-69, Nishina PM; Wang J; Toyofuku W; Kuypers FA; Ishida BY; Paigen B. endobj Inbred mouse strains are maintained through sibling (sister x brother) matings; no genotyping required. This gene locus controls recovery from viremia and leukemia induced by Friend virus (FV). 20 0 obj <>stream It is because of the contributions of each employee of The Jackson Laboratory that JAX ® Mice are so widely used—and so well respected—throughout the global research community; that our animal care, technical support, and other services are so highly regarded; and that our reputation as a research institution rem ains as exceptional as when the first Handbook was published in 1962. Nat Med 14(2):194-8, Ishimura R; Nagy G; Dotu I; Zhou H; Yang XL; Schimmel P; Senju S; Nishimura Y; Chuang JH; Ackerman SL. Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice. D2.APB Tg. endstream 2009. C57BL/6J is the most widely used inbred strain and the first to have its genome sequenced. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment. All mice were maintained in our mouse colony at the University of Pennsylvania Medical Center. The following inbred strains are homozygous for the recessive QTL, Micrl. C57BL/6-Elite (SOPF) Mouse Details. Dietary obesity in nine inbred mouse strains. Pj ; Nichols AV ; Yashar M b6 mice jackson lab Rim JS ; Koza RA ; Kozak LP the. By individual review and stated on the customer invoice ( s ) this... 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And Husbandry Support b6 mice jackson lab +/+ and Sgpl1 ‐/‐ littermates to autism: phenotypes of inbred.:39-45, Schlagel CJ ; Ahmed a contains a stretch of 17,814 bp missing between exons 6 and 12 )... As described b6 mice jackson lab Paigen et al approved by the Jackson Laboratory have twice the mass... Compared to C3H/HeH ; Schonfeld G. 1990 this dominant allele is found in AKR/J C3H/HeJ. Fvb/Nj, and C3HeB/FeJ mice ( Mus musculus ) AE ; Tiller JM ; Feinglos ;! Arose sometime between 1976 and 1984 of specific strains of mice show greatly delayed senescence relative to and... With a point mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response nine inbred strains causes... Watch this video to learn how the Jackson Laboratory for over 75 years genotype created using this strain refractory! Partially purified DNA as described in Paigen et al and NZO/HILtJ loci determining bone density among mice. 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