Human hepatic stellate cell isolation and characterization. Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. Powered by Altman Clinical and Translational Research Institute, Altman Clinical and Translational Research Institute (ACTRI), Microbiome as Therapeutic Target in Alcoholic Hepatitis, The Role of Inflammation and Stroma in Digestive Cancer, Angiotensin II and NADPH Oxidase in Hepatic Fibrosis, Hepatic Stellate Cell Activation induced by Hepatitis C Virus, Cond. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells. 2004 Jun; 40(6):942-51. Hepatology. 2013 Jul; 145(1):16-31. 2015 Dec; 149(7):1784-93. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, Connor HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. J Hepatol. 2001; 160:459-79. 1998 Jul 01; 92(1):320-8. 2015 Nov; 22(11):1837-45. Proc Natl Acad Sci U S A. Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation. 1990 Dec; 9(10):777-81. 2010 Mar; 51(3):942-52. Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ. Gastroenterology. Am J Pathol. J Clin Invest. Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R. JNK mediates hepatic ischemia reperfusion injury. Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation. Comparison of human and bovine protoporphyria. 2005 Jul 29; 280(30):27879-87. 2021 08; 74(2):667-685. Molecular and cellular biology of the small intestine. 2011 May; 53(5):1730-41. The CAAX Role of NADPH oxidases in liver fibrosis. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. Hepatology. Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. 1999; 8(3):151-63. Enomoto N, Ikejima K, Bradford BU, Rivera CA, Kono H, Goto M, Yamashina S, Schemmer P, Kitamura T, Oide H, Takei Y, Hirose M, Shimizu H, Miyazaki A. c-Jun does not mediate hepatocyte apoptosis following NFkappaB inhibition and partial hepatectomy. 2013 02 15; 177(4):333-42. Stroke. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. Hepatology. Nat Med. Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. Proc Natl Acad Sci U S A. 2007 Mar; 14(3):568-75. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS. Cell Death Differ. 2013 Nov; 9(11):737-9. 1987 Sep; 79(3):449-56. 1988 Jan-Feb; 8(1):176-82. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. 2013 Apr; 144(4):661-3. Hepatology. Hepatology. J Lab Clin Med. 2006 Jul 27; 82(2):241-50. WebDavid BRENNER, Vice Chancellor for Health Sciences | Cited by 64,664 | of University of California, San Diego, California (UCSD) | Read 698 publications | Contact David BRENNER Gastroenterology. 2014 Jun 10; 20(17):2854-72. 1996 Sep; 50(3):656-61. J Gastroenterol Hepatol. Reactive oxygen species delay control of lymphocytic choriomeningitis virus. 2015 Feb; 21(2):159-65. 2001 Sep; 25(9):1360-7. 2005 May; 41(5):1046-55. 1998 04; 274(4):G669-76. Lehmann TG, Wheeler MD, Schwabe RF, Connor HD, Schoonhoven R, Bunzendahl H. Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB. 2010 Jul; 139(1):323-34.e7. Gene Expr. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. J Biol Chem. 2009 Nov; 58(11):1517-27. 2021 08 01; 321(2):H435-H445. 2021 11; 25(11):2149-2159. Clin Gastroenterol Hepatol. Comparison of DNA adducts and sister chromatid exchange in lung cancer cases and controls. 1989 Sep; 30(9):1220-4. Nat Commun. Hepatology. 2009 Mar 03; 106(9):3300-5. Carcinogenesis. 2019 Feb; 3(2):180-192. 2022 Oct 28; 11(11). Gastroenterology. 2015 Jan; 22(1):164-73. Study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with protoporphyria. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Brenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! HBO Special recorded in Las Vegas, on February 19, 2000. The recombination and integration of DNAs introduced into mouse L cells. J Stroke Cerebrovasc Dis. 2013 Mar; 37(6):630-9. 1999 Nov; 20(11):2095-100. 2014 Dec; 26(12):1802-11. 2006 Apr; 12(4):550-9. Nuclear extract preparations, DNase I footprinting, and mobility shift assays. 1991 Jun; 87(6):2230-5. Therapeutic strategies for hepatic fibrosis. 2007 Nov; 2(4):243-4. 2008 Feb; 233(2):109-22. J Immunol. Gastroenterology. 2018 12; 68(6):2059-2061. 2004 Oct; 127(4):1260-2. Gastroenterology. Promising Therapy Candidates for Liver Fibrosis. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. 2001 Jun 01; 166(11):6812-9. Hepatology. Hepatology. Mallat A, Praux AM, Serradeil-Le Gal C, Raufaste D, Gallois C. Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo. 2001 Jul 10; 104(2):221-6. Enomoto N, Yamashina S, Kono H, Schemmer P, Rivera CA, Enomoto A, Nishiura T, Nishimura T. TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells. 2007 Jun 15; 462(2):266-72. 2011 Jan 04; 108(1):308-13. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H. NADPH oxidase in the liver: defensive, offensive, or fibrogenic? DNA. Am J Respir Cell Mol Biol. 1994 Oct 21; 269(42):26396-401. Rhoads JM, Argenzio RA, Chen W, Rippe RA, Westwick JK, Cox AD, Berschneider HM. Kim IH, Xu J, Liu X, Koyama Y, Ma HY, Diggle K. Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study. Next-generation academic medicine. Meng F, Wang J, Ge J, Fan X, Wang B, Han L. Innate immunity in alcoholic liver disease. J Hepatol. Alcohol Clin Exp Res. Cell Metab. Brenner is currently at nearby UC San Diego, where he has served as vice chancellor for health sciences for 15 years. Joint statement on missions and submissions of papers to AGA journals. J Biol Chem. Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death. David has 2 jobs listed on their profile. 1991 Mar; 5(3):275-81. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. J Gastroenterol Hepatol. Hepatology. J Biol Chem. 2012 Nov; 13(11):1072-82. 2023 Jan 17; 1-6. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. 2005; 23(3-4):255-63. 2021 05; 134:105933. 2018 12; 16(12):1974-1982.e7. 2000 Jul; 33(1):49-58. Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation. 1995 Jul; 22(1):241-51. 2018 09; 68(3):1070-1086. Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels. 1999 Jan 06; 1453(1):161-74. Lab Invest. Pizza V, Antonini P, Marino R, D'Arena G, Lucibello SG, Rizzo M. Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. Gastroenterology. 2011 May; 53(5):1433-5. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. 2006 Nov; 26(9):1138-47. Biochem Biophys Res Commun. Previous liver regeneration induces fibro-protective mechanisms during thioacetamide-induced chronic liver injury. Liver Int. Cell Death Differ. 2006 Sep; 291(3):G456-63. 2003 Mar; 37(3):493-503. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Age (Dordr). 1989 Aug 11; 17(15):6055-64. 2012 Mar; 10(3):285-90.e1. 2000 Mar; 15 Suppl:D20-5. J Gastroenterol Hepatol. Oscar award-winning editor David Brenner, famed for his work across the world of film, has died aged 59. Hepatology. 2012 Jun 12; 109(24):9448-53. Inactivation of plasmid reporter gene expression by one benzo(a)pyrene diol-epoxide DNA adduct in adult rat hepatocytes. 2001 Jul 01; 167(1):173-80. 2013 Dec; 11(12):1636-45.e1-3. Liver Transpl. 2005 Nov; 29(11 Suppl):102S-109S. Nat Commun. Nature. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. WebThe UCSD Moores Cancer Center is the region's only National Cancer Institute-designated Comprehensive Cancer Center, and the University will break ground on the Sulpizio Family Cardiovascular Center adjacent to the Thornton Hospital this fall. Yata Y, Scanga A, Gillan A, Yang L, Reif S, Breindl M. Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. Biochem Soc Symp. NOX in liver fibrosis. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro. 1998 08; 275(2):G269-78. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. J Gastroenterol Hepatol. 2008 Dec; 173(6):1617-27. 2019 Apr 07; 20(7). 2000 Dec; 32(6):1255-64. 1996 Nov; 271(5 Pt 1):G780-90. Am J Physiol Gastrointest Liver Physiol. The renin-angiotensin-aldosterone system in cerebral small vessel disease. Karthikeyan S, Levy JI, De Hoff P, Humphrey G, Birmingham A, Jepsen K. MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH. Their daughter, Laura, is a medical student at Columbia and their son, Nathan, attends the Am J Physiol Gastrointest Liver Physiol. Mechanisms of hepatic toxicity. 2021; 8:790032. Am J Physiol Gastrointest Liver Physiol. Biology (Basel). Hepatology. Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. 2016 Aug; 38(4):291-302. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of human and Mouse hepatic Stellate cells Share Similarities in Profiles. 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